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HEPA stands for high-efficiency particulate air. A HEPA filter is a type of mechanical air filter; it works by forcing air through a fine mesh that traps harmful particles such as pollen, pet dander, dust mites, and tobacco smoke. How is HEPA made and how does it clean air? The difference between a HEPA filter and other filters is that HEPA filters are made of thin fibers of glass, and contain some level of activated carbon-based material.